IL4 and neoplasm: Among inflammatory markers, IL-1βhas been demonstrated to induce the production of gelatinases, which are family members of the matrix metalloproteinases (MMPs) that contribute to tumor invasion and metastasis [81], whereas IL-4 and IL-10 play a role in immune suppression, and IL-6 plays a role in anti-apoptosis [74] for head and neck cancer.