ALK and laryngotracheoesophageal cleft: Furthermore, patients with ALK-rearranged Sq-LC who received the ALK inhibitor alectinib as second-line chemotherapy were non-responsive and had extremely short PFS with PD as compared to patients with ALK-rearranged Ad-LC (3.3 ± 2.1 vs. 13.7 ± 9.7 months; p = 0.045; Figure 4B).