Mabuchi et al. examined tissue microarrays of 98 primary ovarian cancers (52 clear cell carcinomas (CCCs) and 46 SACs) and showed that AKT, mTORC1 and mTORC2 are more frequently activated in CCC than in SAC [44]. This evidence concerns the gene AKT1 and Charlevoix-Saguenay spastic ataxia.