PIK3CA and cancer: In addition to Oridonin, another 18 extracts from Glycyrrhiza uralensis Fisch or Sophora flavescens Ait inhibited the growth of HMEC-PIK3CAH1047R cells by more than 80% compared to cells treated with DMSO (Supplementary Table 1), suggesting the potential role of other TCM plant extracts in inhibition of PI3K signaling and cancer therapy.