PTEN and breast carcinoma: Notably, Oridonin efficiently prevented the initiation of mouse mammary tumors with PI3KCA mutant cells (Figure 6) suggesting the potential application and advantages of Rabdosia rubescens or its extracts for carriers of breast cancer susceptibility genes who are at high risk of developing breast cancer; for example, carriers of germline PTEN mutation or BRAC1 mutation show increased AKT signaling [26–28].