In addition to Oridonin, another 18 extracts from Glycyrrhiza uralensis Fisch or Sophora flavescens Ait inhibited the growth of HMEC-PIK3CAH1047R cells by more than 80% compared to cells treated with DMSO (Supplementary Table 1), suggesting the potential role of other TCM plant extracts in inhibition of PI3K signaling and cancer therapy. The gene discussed is PIK3CD; the disease is cancer.