Consistent with the results of structure prediction and reporter assays, we found that, as compared with the wild A/A genotype, the heterozygous A/C (P = 0.018) and the A/C+C/C group (P = 0.014) were significantly correlated with lowered expression of SLC31A1 transcript in lung cancer tissues, suggesting that the modulation of rs10759637 on hsa-miR-29−SLC31A1 3′UTR interaction observed in cell line has relevance in clinical samples. The gene discussed is SLC31A1; the disease is lung carcinoma.