We here present evidences that rs10759637 in SLC31A1 3′UTR functionally decreased microRNA-mediated gene expression, and this common non-coding variants as well as linked SNPs were associated with severe hematological toxicities such as thrombocytopenia and shorter overall survival in the Chinese cohort of NSCLC patients with platinum-based chemotherapy. The gene discussed is SLC31A1; the disease is non-small cell lung carcinoma.