MAPT, WNT3, CRHR1, KANSL1, and NSF are located on chromosome 17, locus 133; genetic variants within these genes have been linked to Alzheimer’s disease in APOE e4 carriers53, Parkinson’s disease54–56, neuroticism57, infant head circumference58, intracranial volume59, and subcortical brain region volumes60. Here, CRHR1 is linked to early-onset autosomal dominant Alzheimer disease.