APOE and early-onset autosomal dominant Alzheimer disease: MAPT, WNT3, CRHR1, KANSL1, and NSF are located on chromosome 17, locus 133; genetic variants within these genes have been linked to Alzheimer’s disease in APOE e4 carriers53, Parkinson’s disease54–56, neuroticism57, infant head circumference58, intracranial volume59, and subcortical brain region volumes60.