RAC1 and colorectal carcinoma: Also in CRC cells, LGR5 has been reported to interact and control the IQGAP1–Rac1 pathway.75 The authors showed that LGR5 reduces phosphorylation of IQGAP1 at Ser-1441/1443, thus increasing IQGAP1–Rac1 interaction and enhancing cell–cell adhesion via actin cytoskeleton regulation.