LGR5 and colorectal carcinoma: The authors identified a single nucleotide polymorphism (SNP) in the LGR5 gene (rs17109924) that was significantly associated with reduced TTR.44 In contrast, an allelic variant of the same SNP (rs17109924) predicts better response to 5FU-based adjuvant chemotherapy.45 However, neither study demonstrated how the SNP impacted LGR5 expression, which is crucial given that primary colorectal carcinomas harbouring variant LGR5 genotypes can exhibit significantly lower LGR5 protein expression.37