In support of this, a study by Baker and colleagues noted heterogeneous localisation of LGR5 expression between the serrated (~ 10–20% cases, non-APC mutant) and conventional (~ 80–90% cases, APC mutant) pathways of CRC, which may reflect the variable Wnt signalling status of these pathologies.32 This evidence concerns the gene APC and colorectal carcinoma.