LGR5 is a well-established target of Wnt/β-catenin signalling,16 but evidence from our laboratory has also shown that the PGE2 and EGF signalling pathways can alter LGR5 expression, which impacts the proliferation/survival capacity of human colorectal adenomas.50,51 Collectively, the overexpression of LGR5 in primary tissue, association with poor patient prognosis, and the pro-tumourigenic activity of LGR5 in in vitro functional studies would indicate a pro-oncogenic role for LGR5 in colorectal tumourigenesis. The gene discussed is LGR5; the disease is colorectal adenoma.