LGR5 and neoplasm: Takahashi et al, used qRT-PCR to assess the LGR5 level and arrived at the same conclusion.29 The study by Hsu and colleagues analysed LGR5 expression in the context of treatment response and reported patients with lower LGR5 expression had a better response to 5FU-based therapy.27 Similarly, Stanisavljević et al noted a longer time to tumour recurrence (TTR) from patients with low LGR5 mRNA expression in response to fluoropyrimidine-based adjuvant chemotherapy.43 A further study by the Lenz group examined the clinical relevance of germline LGR5 polymorphisms.