The minor allele frequency (A) in TNFSF13B BAFF-var was statistically significantly higher in SLE patients than in controls in both, the Spanish (p = 0.0001, OR = 1.41, 95% CI = 1.14–1.74) and German (p = 0.030, OR = 1.86, 95% CI = 1.05–3.28) subgroups. Here, TNFSF13B is linked to systemic lupus erythematosus.