More importantly, this increase in CD3+ T-cell population was attributed to a significant increase of CD8+ T cells (Fig. 3d), whether normalized to CD45+ cells (from 25.9 to 45.3%, p ≤ 0.01 by one-way ANOVA, Tukey’s multiple comparison test) (Fig. 3f) or number of tumor-resident cells (from 8 to 19%, p < 0.05 by one-way ANOVA, Tukey’s multiple comparison test) (Supplementary Fig. 4a). The gene discussed is CD8A; the disease is neoplasm.