In addition, MPT0G211 concentration-dependently increased the acetylation of α-tubulin in SH-SY5Y and Neuro-2a cells, the common used neuronal cell lines in the study of AD, at concentrations ranging from 0.1 to 1 μM without affecting the acetylation of histones, which is consistent with the selective inhibition of HDAC6 (Fig. 1b, c). Here, HDAC6 is linked to Alzheimer disease.