MAPT and Alzheimer disease: Immunohistochemical analysis revealed that mutant transgenes mediated increases in total tau and tau phosphorylation at Ser396/Ser404 in the hippocampal CA1 region of mice that harbor tauP301L mutant transgene; MPT0G211 treatment significantly downregulated p-Tau (S396) and p-Tau (S404) expression and increased acetyl-α-tubulin accumulation in the 3×Tg-AD mice brain (Fig. 6b).