Additionally, the treatment of nude mice with MC-3129 increased the cleavage/activation of ROCK1 and the levels of phospho-PTEN, and decreased the levels of phospho-Akt in tumor sections of nude mice, further confirming the antileukemic effect of MC-3129 through interruption of the ROCK1/PTEN/Akt signaling pathway. Here, AKT1 is linked to neoplasm.