In addition, inhibition of Fzd10 could impair TGF-β1-induced myofibroblast differentiation of LR-MSCs and alleviate BLM-induced pulmonary fibrosis (Fig. 9). This finding in the report provides a clear link between Wnt7b/10a, Fzd10 and pulmonary fibrosis, indicating that controlling the synthesis of Wnt proteins could avert the aberrant activation of Wnt signaling and retard the progression of pulmonary fibrosis. This evidence concerns the gene WNT7B and pulmonary fibrosis.