TGFB1 and pulmonary fibrosis: In addition, inhibition of Fzd10 could impair TGF-β1-induced myofibroblast differentiation of LR-MSCs and alleviate BLM-induced pulmonary fibrosis (Fig. 9). This finding in the report provides a clear link between Wnt7b/10a, Fzd10 and pulmonary fibrosis, indicating that controlling the synthesis of Wnt proteins could avert the aberrant activation of Wnt signaling and retard the progression of pulmonary fibrosis.