In addition, abnormal cleavage of NRG1 could contribute to pathophysiology, as mice lacking NRG1 processing enzymes such as BACE1 and neuropsin show schizophrenia-like phenotypes25,26 and one of the few schizophrenia-associated SNPs known to occur in the coding sequence impairs cleavage of NRG1 by γ-secretase27,28. This evidence concerns the gene NRG1 and schizophrenia.