Finally, to evaluate the relevance of deregulated Phf2 activity during non alcoholic fatty liver (NAFL) progression in human, liver biopsies from lean subjects with no fatty liver (NoFL) or obese patients with same BMI and same degree of hepatic steatosis (60%), were obtained from the Biological Atlas of Severe Obesity (ABOS) cohort (Supplementary Tables 4 and 5). This evidence concerns the gene PHF2 and obesity due to melanocortin 4 receptor deficiency.