Finally, we detected the protein expression of CD24, p-AKT, p-mTOR, PP2A-alpha, and cleaved LC3 in the tumor tissues by using IHC staining, and the results indicated that the treatment of CD24shRNA can block CD24-induced autophagy via activation of AKT/mTOR signaling through decreasing the expression of PP2A alpha. The gene discussed is PPP2CA; the disease is neoplasm.