Infection of MEFs with adenoviral Cre resulted in a substantial reduction in STEF expression levels (STEF KO) relative to cells infected with control virus (control), which could be rescued through re-expression of wild-type (WT) STEF via addition of doxycycline (STEF KO + WT STEF) (Fig. 3a). The gene discussed is TIAM2; the disease is infection.