MKNK1 and neoplasm: Previous studies have manifested that apoptotic tumor cells stimulate a small number of surviving tumor cells repopulating which is related to caspase3/iPLA2 /PGE2 pathway4,19, caspase3/7-PKCδ-Akt/p38 MAPK20, and caspase3/PKCδ/p38/MNK1 signaling pathway21.