Clinical sepsis was defined as sepsis with at least two signs (temperature >38 °C or <36.5 °C, tachycardia >200/min, new onset or increased frequency of bradycardias or apneas, hyperglycemia >140 mg/dl, base excess <−10 mval/l, changed skin color, increased oxygen requirements) and one laboratory sign (C-reactive protein >1 mg/dl, immature/neutrophil ratio >0.2, white blood cell count <5/nl, platelet count <100/nl) and antibiotic treatment for ≥5days, but no proof of causative agent in the blood culture. The gene discussed is CRP; the disease is Sepsis.