CRB1 and Leber congenital amaurosis: Of the 12 (nine LCA-associated and three other IRD-associated) genes found to contain potential pathogenic variants, the most frequently mutated genes were CRB1 (8.8%, 3/34), NMNAT1 (8.8%, 3/34), and RPGRIP1 (8.8%, 3/34) (Fig. 1).