Clinical studies have shown that high circulating Gal-3 levels are indicative of severity of heart diseases or associated with increased risk of major adverse cardiovascular events including heart failure (HF)2, arrhythmias3–5, arterial stiffening6, re-hospitalization post-HF discharge7, diastolic dysfunction8, severity of atrial fibrosis5,9 or mortality10,11. Here, LGALS3 is linked to heart failure.