TGFBR2 and neoplasm: 106 upregulated genes that were shared by ES and AS groups represent the tumor-induced pTreg signature (Fig. 2g and Supplementary Data 2) including genes associated with pTreg generation (Pdcd1 and Nfkbid), Treg homeostasis (Pdcd1), and TGFβ sensitivity (Tgfbr2 and Tgfbr3)34–36.