Because the LV may transduce Ag presenting cells (APCs), and the stability of MHC-II peptide complexes on mature dendritic cells (DCs) can last for several weeks in vivo26, an immune response against DBY may be induced in the presence of virus-induced signals, at the time of inoculation, independently of Ag expression by tumor cells. The gene discussed is RENBP; the disease is neoplasm.