The tumor-induced anergic mouse gene signature was significantly enriched in chCD4+ T cells from cancer patients (p = 0.0023) but not from healthy donors (p = 0.275) (Supplementary Fig. 11d), suggesting that CD4+ T cells may also become anergic in tumor bearing patients including NSLC patients (Supplementary Fig. 11c). The gene discussed is CD4; the disease is cancer.