We initially used a model of genetically engineered lung adenocarcinoma that had previously been described28: a bi-cistronic LV encoding both a Luciferase fused to an Ag chosen at will and a Cre recombinase is injected intratracheally (i.t.)into KrasLSL-G12D/+Trp53flox/flox (KP) mice. Here, RENBP is linked to lung adenocarcinoma.