Our previous study also demonstrated that inflammasome activation induced by Gram-negative bacteria Yersinia pestis infection was abrogated in Rip1−/− and Rip3−/−Caspase-8−/− macrophages, but not in Rip3−/− cells14, which is consistent with another independent study using Yersinia pseudotuberculosis12. The gene discussed is RIPK1; the disease is plague.