First, to check whether the YAP pathway was associated with poor colon cancer survival, the PROGene database, which contains tools to enable multiple gene-based prognostic assessment21, was used to determine the correlation between the survival outcome and the YAP signature (YAP1, CTGF, and CYR61) in colon cancer. The gene discussed is CCN1; the disease is malignant colon neoplasm.