YAP is a key downstream effector of the Hippo signaling pathway, which controls organ size, development, and tumorigenesis through the modulation of cell proliferation and apoptosis1,2, and is tightly regulated by upstream kinases and their adaptors, such as Mst1/2, Sav1, and Lats1/2, which exerts tumor suppressive activity in several cancers1,2. The gene discussed is YAP1; the disease is neoplasm.