TGFB1 and neoplasm: In this long phase, the immune system of the host sculpts the immunogenicity of genetically unstable tumor clones, allowing for the selection of resistant tumor cells, thus leading to (3) the escape phase, favored by regulatory (Treg) cells and immunosuppressive cytokines, including transforming growth factor-β (TGF-β), Tumor Necrosis factor (TNF)-α, and Interleukin (IL)-10 [12].