This complex process functions through a mechanism of “immunoediting”, which consists of three sequential phases: (1) the elimination phase, in which growing tumors are effectively recognized and cleared by the synergic actions of innate and adaptive immune responses that also recognize remodeling of stroma and changes in the microenvironment; (2) The equilibrium phase, during which, antigen presenting cells, tumor cells and CD8+ T cells remain in a state of dynamic balance and the surviving tumor cells remain quiescent under the pressure of immune cells. Here, CD8A is linked to neoplasm.