Finally, melatonin also suppresses tumor angiogenesis by inhibiting not only HIF-1α accumulation through suppression of the melatonin nuclear receptor RZR/RORγ and the SUMO-specific protease 1 (SENP1) signaling pathway but also VEGF production in human gastric cancer cells under hypoxia [111]. The gene discussed is HIF1A; the disease is neoplasm.