PRKAA1 and Cachexia: Interestingly, IFNγ/TNFα treatment alone also increased pAMPK and pACC levels at 24 h, corroborating previous reports that AMPK phosphorylation increases during the progression of cachexia‐induced muscle wasting (Fig 1A; Penna et al, 2010; White et al, 2011, 2013).