PRKAA1 and Duchenne muscular dystrophy: Indeed, the therapeutic potential of AMPK activation is further unscored by the fact that AMPK activation can protect muscle in mdx mice (a model of Duchenne's Muscular Dystrophy) and in Angiotensisin II‐driven muscle atrophy (Tabony et al, 2011; Pauly et al, 2012).