ACE2 and preeclampsia: In human decidua, an increase in Agtr1 has been described in preeclampsia.37 Furthermore, an increase in Agtr1 activation via Ang II has been found to reduce the placental transport of system A amino acids.38 Vaswani et al10,11 found a gestational-dependent increase in the gene expression of components of the RAS (eg, Ace2 and Agtr1a) in rodent placenta.