Women with gestational hypertensive complications have varying degrees of severity, and previous studies in normotensive rodents have used doses ranging from 500 to 1000 ng/kg per minute.16,22,30 The method described in the current study creates a robust, easily reproducible model of preeclampsia with potential to vary the cardiovascular insult by modifying the Ang II dose administered. Here, AGT is linked to preeclampsia.