This is in line with human pregnancies where preeclampsia symptoms do not arise until after 20 weeks gestation.31,32 Local tissue Ang II production plays a crucial role in RAS maintenance during pregnancy, and RAS components have been found in both rodent and human placenta.11,33–35 However, any local control of Ang II production by the placenta may be masked by exogenous administration in our model. The gene discussed is AGT; the disease is preeclampsia.