It has been shown that a high fat food feeding in a mutant TAR DNA-binding protein 43-kD (TARDBP)-expressing ALS mouse model extends their lifespans [37], and that the activation of AMP-activated protein kinase (AMPK), which functions as an energy sensor, results in the extension of lifespans in a mutant SOD1-expressing ALS mouse model [38]. Here, TARDBP is linked to amyotrophic lateral sclerosis.