In our investigation, we discovered that anti-apoptotic protein Bcl-2 was downregulated while the levels of pro-apoptotic protein Bax and cleaved Caspase-3 were increased significantly in HCT116 cells after administration of NKP608, which suggested that NKP608, at least partly, induced cell apoptosis in colorectal cancer cells. The gene discussed is BCL2; the disease is colorectal cancer.