It is noteworthy that PAS-5 induced high levels of Tregs at week 3 post-infection, as eosinophils were shown to release granules, as well as certain cytotoxic proteins, such as eosinophil cationic protein and eosinophil protein X, during this time period for killing the larvae [9, 22, 30]. The gene discussed is RNASE3; the disease is infection.