Moreover, in SR of primary cutaneous diffuse large B-cell lymphoma, leg type, immunohistochemical studies demonstrated the presence of lymphocytes positive for CD3, 4, and 8, cytotoxic molecules, granzyme B and T-cell-restricted intracellular antigen (TIA1), both in the vicinity of the tumor nest and in the tumor [21]. The gene discussed is GZMB; the disease is diffuse large B-cell lymphoma.