MAD2L2 and neoplasm: In addition, Niimi K et al. also reported that the expression of DNA damage repair related protein REV7 in OCCC was significantly higher than that in other types of EOCs (73.5% vs 53.4%), and the knockdown of REV gene could induce apoptosis and DNA damage in tumor cells, leading to a significant improvement of chemoresistance to cisplatin in OCCC [15].