The most frequently reported grade 3 toxicity in group A were hyperglycemia (33.3%), thrombocytopenia (29.2%), leukopenia (20.8%), lymphopenia (20.8%), neutropenia (16.7%), and elevated AST (12.5%); in group B, toxicities noted were thrombocytopenia (53.3%), neutropenia (53.3%), leukopenia (33.3%), fatigue (26.7%), elevated ALT (20%), hyponatremia (20%), and acne-like rash (13.3%); and in group C, they were neutropenia (33.3%), leukopenia (33.3%), anemia (13.3%), and fatigue (13.3%). The gene discussed is GPT; the disease is acne.