These include positive associations between OXTR DNAm and callous-unemotional traits in youth [47, 58], social cognitive deficits in ASD [45, 46], rigid thinking in anorexia nervosa [49], affect regulation problems [41, 57] and mood deficits [38–40] as well as limbic regions linked with facial and emotional recognition [48, 50, 51]. This evidence concerns the gene OXTR and Cognitive impairment.