CDKN1A and lung adenocarcinoma: It has been reported that CDKN1A was involved in G1 phase of cell cycle process, cell proliferation and apoptosis [33, 34], which is in accordance with the roles of GMDS in cell proliferation, apoptosis and cell cycle, as GMDS knockdown in lung adenocarcinoma cells led to impaired cell proliferation, enhanced cellular apoptosis and cell cycle retardation at G1 phase revealed in this study.