FOXP3 and chronic obstructive pulmonary disease: There is also the potential for misclassification of Chronic Obstructive Pulmonary Disease (COPD) as asthma in adulthood is an issue that has been discussed elsewhere [20], clustering by pathophysiological parameters (e.g., FOXP3 (Treg)) should be adopted, when this data is available, to determine non-atopic and late-onset asthma in future analyses [21].