Importantly, down-regulation of miR-106a, mediated by PDGF signaling, leads to Twist up-regulation and thus EMT progression in hepatoma cells [179] while the opposite phenotypical consequences are observed by the IL6-mediated regulation of miR-33a leading to Twist downregulation and thus suppression of tumor progression in gallbladder cancer [180]. This evidence concerns the gene TWIST1 and hepatocellular carcinoma.