Feed-forward mechanisms also provide regulatory loops for miR-373, miR-221, miR-424, and Twist [181,182] in different oncogenic processes, involving targeting of the Twist 3′UTR by the corresponding miRNAs and promoter regulation by Twist. In addition, miR-221 and miR-424, Twist-regulated microRNAs, are also involved in EMT regulation, leading to increased metastasis in cervical cancer [183] and breast cancer [184]. The gene discussed is TWIST1; the disease is breast carcinoma.