INS and obesity due to melanocortin 4 receptor deficiency: An increase in muscle HSP70 could signify the prevention or amelioration of the damages caused by a high-fat diet-induced obesity, giving protection against disturbances in metabolic homeostasis, acting in the reduction of inflammation, improvement in oxidative capacity (cellular respiration) [51], reduction in insulin resistance [53], improvement in e glucose tolerance and increase in insulin signaling [57].