Analysis of these genes in patient samples from the TGCA dataset using the MethHC database (methhc.mbc.nctu.edu.tw) confirmed significant hypermethylation of the DKK3, PTGS2, SLC16A5, HFE, and CYP27A1 promoters in prostate tumors, compared to normal prostate. This evidence concerns the gene CYP27A1 and prostate neoplasm.