To study the interactions among RNASEH2A, CDK1, and CD151 and their impact on tumor proliferation, we performed si-RNA knockdown studies on three ccRCC cell lines (786O, A704, KMRC3, all with VHL mutation) and one kidney urothelial carcinoma cell line (BFTC909, without VHL mutation). The gene discussed is CD151; the disease is neoplasm.