VEGFA and neoplasm: Primary tumor-derived secretions that promote pre-metastatic niche construction include TGFβ [18, 21], TNF-α [18], placental growth factor [18, 22], vascular endothelial growth factor [18, 21, 22], lysyl oxidase [19], microvesicles [29], exosomes [20, 26–28], and many more [17, 18].