In the frontal cortex (Fig 2), Stress HF/HFr+CN rats exhibited higher mRNA levels of Pten (p<0.05), Tau (p<0.01) and App (p<0.10) but lower levels of Gys1 (p<0.01) mRNA than Rest HF/HFr+CN rats. The gene discussed is APP; the disease is hydrops fetalis.