SIRT1 and infection: The Silent Information Regulator 1 (SIRT1), a histone deacetylase known to be involved in stress-responsive pathways as inflammation [70, 71, 72], was a miR-217 target that did not show significant differential expression relative to uninfected cells 12 h post infection but presented a significant down-regulation at 24 h post infection (3.45 fold down-regulated), what reinforces that different target genes of the same miRNA have different dynamics of regulation.