Loss-of-function mutations in PARK2 and PINK1, which encode the cytosolic E3 ubiquitin ligase parkin and the mitochondrial ubiquitin kinase PINK1, respectively, are the most prevalent recessive causes of Parkinson’s disease (PD), an age-dependent neurodegenerative disorder (Corti et al., 2011). The gene discussed is PRKN; the disease is Parkinson disease.