CA2 and cancer: Zhou et al. (2015) showed that knockdown of CAII in NCI-H727 and A549 cancer cell lines resulted in significant reduction in clonogenicity in vitro, and in marked suppression of tumor growth in vivo. By using an apoptosis gene array, Zhou et al. (2015) found a novel association of CAII-mediated apoptosis with specific mitochondrial apoptosis–associated proteins.