EMV levels were significantly higher in patients with VTE,43, 73 a previous VTE history,74, 75 and the prothrombin gene mutation G20210A (PTM) compared with controls.74 This finding implies that elevated levels of circulating CD62E+EMVs act as carriers of mild and severe inherited thrombophilia and may contribute to the development of VTE in factor V Leiden (FVL) mutation carriers. The gene discussed is SELE; the disease is Rare hereditary thrombophilia.