Continuous positive airway pressure treatment improves endothelial function in OSA patients.57, 59, 60 Following CPAP treatment, CD62E+ EMVs (but not CD31+/CD42− EMVs) were significantly reduced.25 These findings were also confirmed by Jelic et al.24, who reported elevated levels of EMVs in OSA patients and a trend towards decreased levels following CPAP in a treatment uncontrolled study. This evidence concerns the gene PECAM1 and obstructive sleep apnea syndrome.