MPO and acute respiratory distress syndrome: EMVs derived from plasminogen activator inhibitor‐challenged ECs may contribute to ALI/ARDS development via increased cytokine production and neutrophil recruitment.70 EMVs induced by plasminogen activation inhibitor‐1 (PAI‐1) contribute to lung injury by initiating a cytokine cascade that increases neutrophil recruitment and a subsequent release of myeloperoxidase (MPO).