ENG and pulmonary embolism: demonstrated that CD105+ EMV levels were significantly higher in chronic thromboembolic pulmonary hypertension (CTEPH) patients than in pulmonary embolism (PE) patients and healthy controls.45 Increased generation of CD105+ EMVs in CTEPH likely represents a protective mechanism supporting EC survival and angiogenesis that counteracts the effects of vascular occlusion and endothelial damage.