By using 111In-DTPA-hEGF and the ruthenium-based replication inhibitor [Ru(phen)2(tpphz)]2+ (Ru1), we show how co-delivery results in a substantially greater decrease in cell survival in EGFR-overexpressing oesophageal cancer cells compared to cells with normal EGFR expression. This evidence concerns the gene EGFR and carcinoma of esophagus.