EGFR and carcinoma of esophagus: These cellular responses indicate that nanoparticle-conjugated 111In activates both double-strand break (DSB) damage and single-strand break (SSB) DNA damage response (DDR) signalling after successful cellular internalisation, in agreement with Auger electrons inducing both forms of DNA lesion.14 Together, these findings indicate that dual delivery of Ru1 and 111In results in enhanced DNA damage in oesophageal cancer cells that overexpress EGFR and are consistent with an additive therapeutic relationship between Ru1 and 111In.