Previous studies ever identified that SOX2 was required for cancer cell line progression in lung and esophageal squamous carcinoma, highlighting the importance of SOX2 as a lineage‐survival oncogene.27 High SOX2 expression has been associated with several human solid tumours, including glioma.28 The present study evaluated that expression of SOX2 mRNA in glioma stem cells was significantly higher than that in glioma cells detected by qRT‐PCR (Figure 5A, P < .001). Here, SOX2 is linked to central nervous system cancer.