Earlier studies have reported that miR‐129‐2 suppressed glioma by targeting HMGB1 in glioma in an DNA methylation way.33 MiR‐129 also impair human malignant glioma progression via autophagic flux enhancement by regulating a novel Notch‐1/ E2F7/Beclin‐1 axis.18 Kang et al34 revealed that miR‐129‐2 suppressed proliferation of esophageal carcinoma cells through down‐regulation of SOX4 expression. Here, HMGB1 is linked to carcinoma of esophagus.