SRY (sex determining region Y)‐box 2 (SOX2) is revealed as a stemness marker in glioma 19 and a transcription factor highly associated with pluripotency.20 Current study investigated the relationship between SOX2 and miR‐129 to further elucidate the molecule network of miR‐129 in glioma stem cells progression. Here, SOX2 is linked to glioma.