POMC and polycystic ovary syndrome: Based on previously published data that androgens regulate granulosa cell POMC expression [20], we evaluated women with PCOS and biochemical hyperandrogenemia (n = 5) and repeated the above described regression analysis, showing that T was the only highly predictive variable for beta endorphin levels in FF (r2 = 0.899, p = 0.014) (Fig. 2).