For instance, overexpression of MEG3 suppressed significantly chronic myeloid leukemia cell growth and invasion by regulating the expression of miR-184 [9], MEG3 inhibited breast cancer cell growth and metastasis by blocking AKT pathway [10], and MEG3 limited EMT processing of breast cancer cell through regulating E-cadherin expression mediated by targeting miR-421 [11]. This evidence concerns the gene MEG3 and breast carcinoma.